http://www.europeanurology.com European Urology RSS feed of the articles currently in press. AIMS AND SCOPE Elsevier is the publisher of European Urology, the official journal of the European Association of Urology. European Urology publishes peer-reviewed original articles and topical reviews on a wide range of urological problems. Topics such as oncology, impotence, infertility, pediatrics, lithiasis and endourology, as well as recent advances in techniques, instrumentation, surgery and pediatric urology provide readers with a complete guide to international developments in urology. Published monthly, European Urology is an important journal for all clinicians and researchers in this field. All members of the EAU receive the journal as a benefit of their membership. For more information on the European Association of Urology, please go to: http://www.uroweb.org Supplements to European Urology are published under the title European Urology Supplements (ISSN 1569-9056). 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All rights reserved. http://www.europeanurology.com/article/S0302-2838(13)00500-9/abstract Thu, 23 May 2013 06:55:01 GMT S0302-2838(13)00500-9 http://www.europeanurology.com/article/S0302-2838(13)00489-2/abstract Wed, 22 May 2013 04:05:01 GMT S0302-2838(13)00489-2 http://www.europeanurology.com/article/S0302-2838(13)00492-2/abstract Sun, 19 May 2013 03:46:06 GMT S0302-2838(13)00492-2 http://www.europeanurology.com/article/S0302-2838(13)00494-6/abstract Sun, 19 May 2013 03:46:04 GMT S0302-2838(13)00494-6 http://www.europeanurology.com/article/S0302-2838(13)00495-8/abstract Sun, 19 May 2013 03:45:01 GMT S0302-2838(13)00495-8 http://www.europeanurology.com/article/S0302-2838(13)00497-1/abstract Sat, 18 May 2013 03:45:04 GMT S0302-2838(13)00497-1 http://www.europeanurology.com/article/S0302-2838(13)00493-4/abstract Sat, 18 May 2013 03:45:02 GMT S0302-2838(13)00493-4 http://www.europeanurology.com/article/S0302-2838(13)00498-3/abstract Sat, 18 May 2013 03:45:01 GMT S0302-2838(13)00498-3 http://www.europeanurology.com/article/S0302-2838(13)00491-0/abstract Fri, 17 May 2013 04:06:56 GMT S0302-2838(13)00491-0 http://www.europeanurology.com/article/S0302-2838(13)00490-9/abstract 80 yr of age, a general age of 70 yr to discontinue screening might be too low. Instead, a flexible age to discontinue based on individual risk stratification should be recommended.Discontinuation of prostate cancer screening at 70 yr of age may be too early, at least in healthy men. Instead, the age to discontinue screening should be flexible based on risk stratification and life expectancy.]]> Fri, 17 May 2013 04:05:34 GMT S0302-2838(13)00490-9 http://www.europeanurology.com/article/S0302-2838(13)00473-9/abstract Thu, 16 May 2013 03:45:03 GMT S0302-2838(13)00473-9 http://www.europeanurology.com/article/S0302-2838(13)00487-9/abstract Wed, 15 May 2013 04:06:02 GMT S0302-2838(13)00487-9 http://www.europeanurology.com/article/S0302-2838(13)00485-5/abstract Wed, 15 May 2013 04:05:44 GMT S0302-2838(13)00485-5 http://www.europeanurology.com/article/S0302-2838(13)00488-0/abstract Wed, 15 May 2013 04:05:08 GMT S0302-2838(13)00488-0 http://www.europeanurology.com/article/S0302-2838(13)00482-X/abstract Tue, 14 May 2013 03:39:41 GMT S0302-2838(13)00482-X http://www.europeanurology.com/article/S0302-2838(13)00474-0/abstract Tue, 14 May 2013 03:39:28 GMT S0302-2838(13)00474-0 http://www.europeanurology.com/article/S0302-2838(13)00484-3/abstract Tue, 14 May 2013 03:38:41 GMT S0302-2838(13)00484-3 http://www.europeanurology.com/article/S0302-2838(13)00481-8/abstract Tue, 14 May 2013 03:37:05 GMT S0302-2838(13)00481-8 http://www.europeanurology.com/article/S0302-2838(13)00483-1/abstract Tue, 14 May 2013 03:35:03 GMT S0302-2838(13)00483-1 http://www.europeanurology.com/article/S0302-2838(13)00465-X/abstract Wed, 08 May 2013 04:05:46 GMT S0302-2838(13)00465-X http://www.europeanurology.com/article/S0302-2838(13)00466-1/abstract Wed, 08 May 2013 04:05:05 GMT S0302-2838(13)00466-1 http://www.europeanurology.com/article/S0302-2838(13)00375-8/abstract Wed, 08 May 2013 03:45:02 GMT S0302-2838(13)00375-8 http://www.europeanurology.com/article/S0302-2838(13)00422-3/abstract Mon, 06 May 2013 12:45:31 GMT S0302-2838(13)00422-3 http://www.europeanurology.com/article/S0302-2838(13)00457-0/abstract 0.5 cm3, or any Gleason grade ≥4) based on clinical predictors (age, stage, PSA, biopsy findings) with and without levels of four kallikrein markers in blood.Results and limitations:A total of 261 patients (67%) had significant disease on pathologic evaluation of the RP specimen. While the clinical model had good accuracy in predicting aggressive disease, reflected in a corrected AUC of 0.81, the four kallikrein markers enhanced the base model, with an AUC of 0.84 (p < 0.0005). The model retained its ability in patients with low-risk and very-low-risk disease and in comparison with the Steyerberg nomogram, a published prediction model. Clinical application of the model incorporating the kallikrein markers would reduce rates of surgery by 135 of 1000 patients overall and 110 of 334 patients with pathologically insignificant disease. A limitation of the present study is that clinicians may be hesitant to make recommendations against active treatment on the basis of a statistical model.Conclusions:Our study provided proof of principle that predictions based on levels of four kallikrein markers in blood distinguish between pathologically insignificant and aggressive disease after RP with good accuracy. In the future, clinical use of the model could potentially reduce rates of immediate unnecessary active treatment.Predictions based on levels of four kallikrein markers in blood—total prostate-specific antigen (PSA), free PSA, intact PSA, and kallikrein-related peptidase 2—can accurately distinguish between pathologically insignificant and aggressive disease after radical prostatectomy. Clinical use of the model could reduce rates of unnecessary surgery.]]> Mon, 06 May 2013 12:45:24 GMT S0302-2838(13)00457-0 http://www.europeanurology.com/article/S0302-2838(13)00458-2/abstract Mon, 06 May 2013 12:45:20 GMT S0302-2838(13)00458-2