European Urology - Current issue http://www.europeanurology.com European Urology RSS feed of the current issue. AIMS AND SCOPE Elsevier is the publisher of European Urology, the official journal of the European Association of Urology. European Urology publishes peer-reviewed original articles and topical reviews on a wide range of urological problems. Topics such as oncology, impotence, infertility, pediatrics, lithiasis and endourology, as well as recent advances in techniques, instrumentation, surgery and pediatric urology provide readers with a complete guide to international developments in urology. Published monthly, European Urology is an important journal for all clinicians and researchers in this field. All members of the EAU receive the journal as a benefit of their membership. For more information on the European Association of Urology, please go to: http://www.uroweb.org Supplements to European Urology are published under the title European Urology Supplements (ISSN 1569-9056). All subscribers to European Urology automatically receive this publication. You can also visit the EAU-EBU Update Series (ISSN 1871-2592). en-US © 2013 Published by Elsevier Inc. All rights reserved. <![CDATA[Re: Do Adenocarcinomas of the Prostate with Gleason Score (GS) 6 Have the Potential to Metastasize to Lymph Nodes?]]> http://www.europeanurology.com/article/S0302-2838(13)00126-7/abstract Mon, 29 Apr 2013 14:27:41 GMT S0302-2838(13)00126-7 <![CDATA[Re: Abiraterone in Metastatic Prostate Cancer Without Previous Chemotherapy]]> http://www.europeanurology.com/article/S0302-2838(13)00127-9/abstract Mon, 29 Apr 2013 14:27:40 GMT S0302-2838(13)00127-9 <![CDATA[Re: Marital Status: A Gender-independent Risk Factor for Poorer Survival After Radical Cystectomy]]> http://www.europeanurology.com/article/S0302-2838(13)00128-0/abstract Mon, 29 Apr 2013 14:27:40 GMT S0302-2838(13)00128-0 <![CDATA[Re: Population Based Study of Long-Term Rates of Surgery for Urinary Incontinence After Radical Prostatectomy for Prostate Cancer]]> http://www.europeanurology.com/article/S0302-2838(13)00129-2/abstract Mon, 29 Apr 2013 14:27:39 GMT S0302-2838(13)00129-2 <![CDATA[Re: Objective Measures of Renal Mass Anatomic Complexity Predict Rates of Major Complications Following Partial Nephrectomy]]> http://www.europeanurology.com/article/S0302-2838(13)00130-9/abstract Mon, 29 Apr 2013 14:27:39 GMT S0302-2838(13)00130-9 <![CDATA[Re: Precise Segmental Renal Artery Clamping Under the Guidance of Dual-source Computed Tomography Angiography During Laparoscopic Partial Nephrectomy]]> http://www.europeanurology.com/article/S0302-2838(13)00131-0/abstract Mon, 29 Apr 2013 14:27:38 GMT S0302-2838(13)00131-0 <![CDATA[Congress Calendar]]> http://www.europeanurology.com/article/S0302-2838(13)00195-4/abstract Mon, 29 Apr 2013 14:27:26 GMT S0302-2838(13)00195-4 <![CDATA[Award pages]]> http://www.europeanurology.com/article/S0302-2838(13)00176-0/abstract Mon, 29 Apr 2013 14:27:26 GMT S0302-2838(13)00176-0 <![CDATA[Editorial Board]]> http://www.europeanurology.com/article/S0302-2838(13)00175-9/abstract Mon, 29 Apr 2013 14:27:24 GMT S0302-2838(13)00175-9 <![CDATA[Contents]]> http://www.europeanurology.com/article/S0302-2838(13)00178-4/abstract Mon, 29 Apr 2013 14:27:24 GMT S0302-2838(13)00178-4 <![CDATA[Reply from Authors re: Behfar Ehdaie, Karim A. Touijer. 5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice. Eur Urol 2013;63:7889]]> http://www.europeanurology.com/article/S0302-2838(13)00117-6/abstract Mon, 18 Feb 2013 11:45:04 GMT S0302-2838(13)00117-6 <![CDATA[Renal Cancer Therapy: Going Forward by Going Backward?]]> http://www.europeanurology.com/article/S0302-2838(13)00118-8/abstract Mon, 18 Feb 2013 10:25:01 GMT S0302-2838(13)00118-8 <![CDATA[A System for Long-term Urodynamic Studies Without Catheters]]> http://www.europeanurology.com/article/S0302-2838(13)00098-5/abstract Mon, 18 Feb 2013 09:45:36 GMT S0302-2838(13)00098-5 <![CDATA[To Transfuse or Not to Transfuse: Is It Really a Question?]]> http://www.europeanurology.com/article/S0302-2838(13)00100-0/abstract Mon, 18 Feb 2013 09:45:02 GMT S0302-2838(13)00100-0 <![CDATA[Obesity, Nutrition, and Prostate Cancer: Insights and Issues]]> http://www.europeanurology.com/article/S0302-2838(13)00102-4/abstract Thu, 07 Feb 2013 17:25:03 GMT S0302-2838(13)00102-4 <![CDATA[Comparative Effectiveness and Safety of Oral Phosphodiesterase Type 5 Inhibitors for Erectile Dysfunction: A Systematic Review and Network Meta-analysis]]> http://www.europeanurology.com/article/S0302-2838(13)00024-9/abstract Thu, 07 Feb 2013 17:15:04 GMT S0302-2838(13)00024-9 <![CDATA[Reply from Authors re: Peter J. Gilling. Laser Enucleation Is Increasingly Becoming the Standard of Care for Treatment of Benign Prostatic Hyperplasia of All Sizes. Eur Urol 2013;63:8689]]> http://www.europeanurology.com/article/S0302-2838(13)00093-6/abstract Thu, 07 Feb 2013 17:15:01 GMT S0302-2838(13)00093-6 <![CDATA[Re: Maxine Sun, Marco Bianchi, Jens Hansen, et al. Chronic Kidney Disease After Nephrectomy in Patients with Small Renal Masses: A Retrospective Observational Analysis. Eur Urol 2012;62:696703]]> http://www.europeanurology.com/article/S0302-2838(13)00090-0/abstract Thu, 07 Feb 2013 16:25:11 GMT S0302-2838(13)00090-0 <![CDATA[Reply to Georgios Papadopoulos, Georgios Stathouros and Konstantinos Doumas Letter to the Editor re: Maxine Sun, Marco Bianchi, Jens Hansen, et al. Chronic Kidney Disease After Nephrectomy in Patients with Small Renal Masses: A Retrospective Observational Analysis. Eur Urol 2012;62:696703]]> http://www.europeanurology.com/article/S0302-2838(13)00091-2/abstract Thu, 07 Feb 2013 16:25:09 GMT S0302-2838(13)00091-2 <![CDATA[TVT-O: A New Gold Standard Surgical Treatment of Female Stress Urinary Incontinence?]]> http://www.europeanurology.com/article/S0302-2838(13)00029-8/abstract Wed, 23 Jan 2013 14:15:06 GMT S0302-2838(13)00029-8 <![CDATA[Radical Locoregional Therapy for Bladder Cancer: Underutilized, or Unsuitable in Many?]]> http://www.europeanurology.com/article/S0302-2838(13)00002-X/abstract Wed, 23 Jan 2013 11:55:04 GMT S0302-2838(13)00002-X <![CDATA[The Impact of Perioperative Blood Transfusion on Cancer Recurrence and Survival Following Radical Cystectomy]]> http://www.europeanurology.com/article/S0302-2838(13)00007-9/abstract Thu, 17 Jan 2013 13:55:02 GMT S0302-2838(13)00007-9 <![CDATA[Laser Enucleation Is Increasingly Becoming the Standard of Care for Treatment of Benign Prostatic Hyperplasia of All Sizes]]> http://www.europeanurology.com/article/S0302-2838(13)00004-3/abstract Thu, 17 Jan 2013 13:35:08 GMT S0302-2838(13)00004-3 <![CDATA[5-Alpha Reductase Inhibitors in Prostate Cancer: From Clinical Trials to Clinical Practice]]> http://www.europeanurology.com/article/S0302-2838(12)01565-5/abstract Tue, 08 Jan 2013 09:15:05 GMT S0302-2838(12)01565-5 <![CDATA[TVT-O for the Treatment of Pure Urodynamic Stress Incontinence: Efficacy, Adverse Effects, and Prognostic Factors at 5-Year Follow-up]]> http://www.europeanurology.com/article/S0302-2838(12)01491-1/abstract Mon, 31 Dec 2012 11:45:01 GMT S0302-2838(12)01491-1 <![CDATA[Complications and Early Postoperative Outcome in 1080 Patients After Thulium Vapoenucleation of the Prostate: Results at a Single Institution]]> http://www.europeanurology.com/article/S0302-2838(12)01423-6/abstract Mon, 03 Dec 2012 09:25:14 GMT S0302-2838(12)01423-6 <![CDATA[Reply from Author re: Maurizio Brausi, Salvatore Siracusano. Collateral Activity of Immunotherapy with Bacillus Calmette-Gurin for the Treatment of Nonmuscle-invasive Transitional Cell Carcinoma of the Bladder: New Insights. Eur Urol 2013;63:8367]]> http://www.europeanurology.com/article/S0302-2838(12)01420-0/abstract Mon, 03 Dec 2012 09:05:19 GMT S0302-2838(12)01420-0 <![CDATA[Development of Accurate Models for Individualized Prediction of Survival After Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma]]> http://www.europeanurology.com/article/S0302-2838(12)01415-7/abstract Tue, 27 Nov 2012 11:15:33 GMT S0302-2838(12)01415-7 <![CDATA[Use of Potentially Curative Therapies for Muscle-invasive Bladder Cancer in the United States: Results from the National Cancer Data Base]]> http://www.europeanurology.com/article/S0302-2838(12)01346-2/abstract Fri, 23 Nov 2012 10:35:06 GMT S0302-2838(12)01346-2 <![CDATA[Dutasteride Treatment Over 2 Years Delays Prostate-specific Antigen Progression in Patients with Biochemical Failure After Radical Therapy for Prostate Cancer: Results from the Randomised, Placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS)]]> http://www.europeanurology.com/article/S0302-2838(12)01337-1/abstract Fri, 23 Nov 2012 10:15:09 GMT S0302-2838(12)01337-1 <![CDATA[Feasibility of Robotic Laparoendoscopic Single-Site Partial Nephrectomy for Renal Tumors >4cm]]> http://www.europeanurology.com/article/S0302-2838(12)01406-6/abstract 4 cm.Objectives:To evaluate the feasibility of robotic LESS PN for renal tumors >4 cm.Design, setting, and participants:Data from 67 consecutive patients who underwent robotic LESS PN were collected between May 2009 to January 2011.Outcome measurements and statistical analysis:Patients were stratified into two groups: 20 patients with renal tumors >4 cm (group 1) and 47 patients with renal tumors ≤4 cm (group 2). Perioperative data were recorded and comparisons between the two groups were analyzed using the Mann-Whitney U test for continuous variables and Fisher exact test for categorical variables.Results and limitations:No statistically significant differences were found between the two groups in demographic information, operative complications, pathologic characteristics, mean decline in estimated glomerular filtration rate, estimated blood loss, operative times, conversion rate, or positive surgical margins. However, group 1 had a higher mean nephrometry score (p 4 cm. Patients with tumors >4 cm had a statistically significant, higher mean nephrometry score, longer warm ischemia time, and longer length of stay, but there was no increased risk of adverse outcomes. A long-term study is needed to confirm the durable renal preservation and oncologic outcomes for patients with larger tumor burden.Patients who underwent robotic laparoendoscopic single-site partial nephrectomy for renal tumors >4 cm had a statistically significant, higher mean nephrometry score and longer warm ischemia time and length of hospital stay but no increased risk of adverse outcomes.]]> Fri, 23 Nov 2012 10:05:09 GMT S0302-2838(12)01406-6 <![CDATA[Collateral Activity of Immunotherapy with Bacillus Calmette-Gurin for the Treatment of Nonmuscle-invasive Transitional Cell Carcinoma of the Bladder: New Insights]]> http://www.europeanurology.com/article/S0302-2838(12)01408-X/abstract Fri, 23 Nov 2012 10:05:02 GMT S0302-2838(12)01408-X <![CDATA[The Relationship Between Nutrition and Prostate Cancer: Is More Always Better?]]> http://www.europeanurology.com/article/S0302-2838(12)01343-7/abstract Fri, 23 Nov 2012 09:55:21 GMT S0302-2838(12)01343-7 <![CDATA[Obesity and Prostate Cancer: Weighing the Evidence]]> http://www.europeanurology.com/article/S0302-2838(12)01344-9/abstract Fri, 23 Nov 2012 09:55:12 GMT S0302-2838(12)01344-9 <![CDATA[National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) Symptom Evaluation in Multinational Cohorts of Patients with Chronic Prostatitis/Chronic Pelvic Pain Syndrome]]> http://www.europeanurology.com/article/S0302-2838(12)01273-0/abstract Fri, 02 Nov 2012 03:46:40 GMT S0302-2838(12)01273-0 <![CDATA[Occlusion Angiography Using Intraoperative Contrast-enhanced Ultrasound Scan (CEUS): A Novel Technique Demonstrating Segmental Renal Blood Supply to Assist Zero-ischaemia Robot-assisted Partial Nephrectomy]]> http://www.europeanurology.com/article/S0302-2838(12)01253-5/abstract Wed, 24 Oct 2012 06:05:02 GMT S0302-2838(12)01253-5 <![CDATA[Contemporary Grading for Prostate Cancer: Implications for Patient Care]]> http://www.europeanurology.com/article/S0302-2838(12)01234-1/abstract Thu, 18 Oct 2012 02:35:01 GMT S0302-2838(12)01234-1 <![CDATA[Novel Immunotherapeutic Strategies in Development for Renal Cell Carcinoma]]> http://www.europeanurology.com/article/S0302-2838(12)01225-0/abstract Sat, 13 Oct 2012 02:37:16 GMT S0302-2838(12)01225-0 <![CDATA[Reply from Authors re: James W.F. Catto, Shahrokh F. Shariat. The Changing Face of Renal Cell Carcinoma: The Impact of Systematic Genetic Sequencing on Our Understanding of This Tumor's Biology. Eur Urol 2013;63:8557]]> http://www.europeanurology.com/article/S0302-2838(12)01142-6/abstract Tue, 02 Oct 2012 02:45:02 GMT S0302-2838(12)01142-6 <![CDATA[Clinical and Pathologic Impact of Select Chromatin-modulating Tumor Suppressors in Clear Cell Renal Cell Carcinoma]]> http://www.europeanurology.com/article/S0302-2838(12)01028-7/abstract Thu, 27 Sep 2012 02:36:11 GMT S0302-2838(12)01028-7 <![CDATA[The Changing Face of Renal Cell Carcinoma: The Impact of Systematic Genetic Sequencing on Our Understanding of This Tumor's Biology]]> http://www.europeanurology.com/article/S0302-2838(12)01117-7/abstract Thu, 27 Sep 2012 02:36:04 GMT S0302-2838(12)01117-7 <![CDATA[A Phase 3, Double-blind, Randomised, Parallel-group, Placebo-controlled Study of Oral Weekly Alendronate for the Prevention of Androgen Deprivation Bone Loss in Nonmetastatic Prostate Cancer: The Cancer and Osteoporosis Research with Alendronate and Leuprolide (CORAL) Study]]> http://www.europeanurology.com/article/S0302-2838(12)01030-5/abstract Wed, 12 Sep 2012 02:35:47 GMT S0302-2838(12)01030-5 <![CDATA[The Promise of Choline-PET/CT in the Detection of Recurrent Prostate Cancer: What Are the Limits of Our Investigation?]]> http://www.europeanurology.com/article/S0302-2838(12)01024-X/abstract Tue, 11 Sep 2012 02:45:46 GMT S0302-2838(12)01024-X <![CDATA[Targeted Next-generation Sequencing of Advanced Prostate Cancer Identifies Potential Therapeutic Targets and Disease Heterogeneity]]> http://www.europeanurology.com/article/S0302-2838(12)01006-8/abstract 900X. Overall, 44% of CRPCs harbored genomic alterations involving the androgen receptor gene (AR), including AR copy number gain (24% of CRPCs) or AR point mutation (20% of CRPCs). Other recurrent mutations included transmembrane protease, serine 2 gene (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (avian) gene (ERG) fusion (44%); phosphatase and tensin homolog gene (PTEN) loss (44%); tumor protein p53 gene (TP53) mutation (40%); retinoblastoma gene (RB) loss (28%); v-myc myelocytomatosis viral oncogene homolog (avian) gene (MYC) gain (12%); and phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit α gene (PIK3CA) mutation (4%). There was a high incidence of genomic alterations involving key genes important for DNA repair, including breast cancer 2, early onset gene (BRCA2) loss (12%) and ataxia telangiectasia mutated gene (ATM) mutations (8%); these alterations are potentially targetable with poly(adenosine diphosphate-ribose)polymerase inhibitors. A novel and actionable rearrangement involving the v-raf murine sarcoma viral oncogene homolog B1 gene (BRAF) was also detected.Conclusions:This first-in-principle study demonstrates the feasibility of performing in-depth DNA analyses using FFPE tissue and brings new insight toward understanding the genomic landscape within advanced PCa.We describe and validate an approach for performing next-generation sequencing at >900X coverage that is amenable to formalin-fixed paraffin-embedded biopsy material. This work identifies novel targetable alterations in advanced prostate cancer and mutations associated with disease progression and tumor resistance.]]> Thu, 06 Sep 2012 02:55:12 GMT S0302-2838(12)01006-8 <![CDATA[Intravesical Bacille Calmette-Gurin Eradicates Bacteriuria in Antibiotic-nave Bladder Cancer Patients]]> http://www.europeanurology.com/article/S0302-2838(12)00948-7/abstract Tue, 21 Aug 2012 02:45:01 GMT S0302-2838(12)00948-7 <![CDATA[18F-Fluoroethylcholine PET/CT Identifies Lymph Node Metastasis in Patients with Prostate-Specific Antigen Failure After Radical Prostatectomy but Underestimates Its Extent]]> http://www.europeanurology.com/article/S0302-2838(12)00927-X/abstract Fri, 10 Aug 2012 02:35:14 GMT S0302-2838(12)00927-X <![CDATA[Reflex ImmunoCyt Testing for the Diagnosis of Bladder Cancer in Patients with Atypical Urine Cytology]]> http://www.europeanurology.com/article/S0302-2838(12)00485-X/abstract Sat, 14 Apr 2012 02:45:33 GMT S0302-2838(12)00485-X