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Progression of metastasis in patient 1: (a) Left pulmonary metastasis before sunitinib treatment; (b) partial remission under treatment (this lesion was subsequently resected [negative margins]); (c) new metastasis at different site 6 mo after sunitinib discontinuation; (d) partial response after retreatment with one cycle of sunitinib; (e) new soft-tissue metastasis in the gluteus muscle undetectable under treatment; (f) appearance 6 mo after discontinuation of sunitinib; and (g) complete resolution after retreatment with one cycle of sunitinib.
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