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The mTOR-induced pathway. Activation of mTOR results in the stimulation of the translational process, triggering the production of growth factors including VEGF (vascular endothelial growth factor). Control of mTOR activation is targeted within the PI3 kinase pathway. PI3K: phosphatidylinositol 3-kinase; mTOR: mammalian target of rapamycin; S6K: ribosomal S6 kinase; 4EBP1: eukaryotic translation initiation factor 4E binding protein; PTEN: phosphatase and tensin homolog deleted on chromosome ten; TSC: tuberosis sclerosis complex.
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