Representative panel of P4, P4-2, T4, T4-2 tumors and metastases (main image, ×4 magnification; insert ×20 magnification): (a) primary tumor P4, solid invasive growth with hypervascularization; (b) lymph node metastasis P4-2, glandular structures in the lymph node tissue; (c) nodular lung metastasis T4-2, solid; (d) bone metastasis P4-2 spinal column with destruction of cortical bone and periosteal growth of tumor cells. Bone metastases were mostly micrometastatic.
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