• Despite substantial progress in the detection and management of mRCC in recent years, the incidence of mRCC is increasing and the disease is still considered incurable
• However, the development and approval of new targeted agents have revolutionized the treatment of mRCC over the past decade by demonstrating clinical benefits over the previous standard of care
• Clinicians are continually challenged as to how best to provide patients with the most appropriate therapy
• Key goals include identifying markers of disease, prognosis and patients' response to treatment
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