• 230 consecutive patients treated with radical prostatectomy and bilateral lymphadenectomy for clinically localized prostatic adenocarcinoma (clinical stage T1 to T2)
• Immunohistochemical staining for uPA, uPAR, and PAI-1 were carried out on serial archival tissue microarray specimens
• These markers were histologically categorized as normal or overexpressed
• Disease recurrence was classified as aggressive if metastases were present, if post-recurrence PSADT was <10 mo, or if the patients failed to respond to salvage local radiation therapy
• The Kaplan-Meier method was used to calculate survival functions
• Univariable and multivariable survival analyses were performed using Cox proportional hazards regression models
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