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6 slide in article Mutations in Metanephric Adenoma of the Kidney
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S0302-2838(12)00635-5.title
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Title
BRAF Mutations in Metanephric Adenoma of the Kidney
Toni K. Choueiri, John Cheville, Emanuele Palescandolo, André P. Fay, Philip W. Kantoff, Michael B. Atkins, Jesse K. McKenney, Victoria Brown, ... BRAF Mutations in Metanephric Adenoma of the Kidney Toni K. Choueiri, John Cheville, Emanuele ... Zoom - S0302-2838(12)00635-5.introduction drag remove slide Introduction • Metanephric adenoma (MA) is a rare kidney neoplasm recognized by the 2004 World Health Organization classification of kidney tumors with an incidence of approximately 0.21%, likely higher ... • Metanephric adenoma (MA) is a rare kidney neoplasm recognized by the 2004 World Health ... Zoom
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Representative microscopic images (×400) of a BRAF-mutant metanephric ...
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S0302-2838(12)00635-5.materials_and_methods
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Materials and methods
• Multiplexed mass spectrometric genotyping was performed on 29 MA cases after tumor DNA extraction.
• We also conducted a mutational screen in an additional 129 renal ... • Multiplexed mass spectrometric genotyping was performed on 29 MA cases after tumor DNA ... Zoom -
S0302-2838(12)00635-5.results
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Results
• We identified the v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E mutation in 26 of 29 MA cases.
• BRAF mutations were rare in the other 129 non-MA renal neoplasms that ... • We identified the v-raf murine sarcoma viral oncogene homolog B1 (BRAF) V600E mutation in 26 ... Zoom -
S0302-2838(12)00635-5.conclusion
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Conclusion
• Metanephric adenoma (MA) of the kidney is a benign tumor that is difficult to differentiate from renal cell carcinoma.
• BRAF V600E mutations are present in approximately 90% of all MA ... • Metanephric adenoma (MA) of the kidney is a benign tumor that is difficult to differentiate ... Zoom
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