Articles

Patient Risk Profiles for Progression of Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (LUTS/BPH)

By: and Franklin C. Lowe*

Published online: 17 January 2014

Keywords: Lower urinary tract symptoms, Benign prostatic hyperplasia, Disease progression, Acute urinary retention, Surgery, Risk factors

Abstract Full Text Full Text PDF (145 KB)

Abstract

Lower urinary tract symptoms suggestive of benign prostatic disease (LUTS/BPH) wax and wane over time but overall there is a slow worsening of symptoms in the long term. Although the majority of patients progress due to symptomatic worsening, some patients are also at risk of developing acute urinary retention (AUR) and/or will need prostatic surgery. In the day-to-day management of LUTS/BPH patients, it is important to know which patients will progress and/or which factors/clinical variables can predict which progression. This is necessary in order to determine “who to treat and how to treat”. This review article on risk factors/clinical variables indicates that for the overall risk of disease progression, a high post-void residual (PVR) and low maximum flow rate (Qmax; factors believed to be predictive for obstruction) are the most important risk factors followed by severe symptoms and a large prostate volume/high prostate specific antigen (PSA). A large prostate volume/high PSA (factors believed to be associated with prostate growth) are most predictive for the occurrence of AUR.

Keywords: Lower urinary tract symptoms, Benign prostatic hyperplasia, Disease progression, Acute urinary retention, Surgery, Risk factors.

Footnotes

College of Physicians and Surgeons, Columbia University, St. Luke's/Roosevelt Hospital, 425 West 59th Street, Suite 3A, New York, NY 10019, USA

* Tel. +1 212 523 7790; Fax: +1 212 523 8816.