Reports suggest that cystectomy following pelvic irradiation is associated with a higher morbidity and mortality than in primary cases. However, such reports are from an era when postcystectomy complication rates were higher than are currently reported.
This study evaluates perioperative complications and mortality in primary radical and postradiation salvage cystectomy.
Design, setting, and participants
Patients treated with cystectomy for bladder cancer or advanced pelvic malignancies involving the bladder were studied.
Perioperative complications and mortality were analysed for 426 primary and 420 salvage cystectomies performed at a single institution between 1970 and 2005.
Results and limitations
The 30- and 60-d mortality in the 2000–2005 cohort were 0% and 1.2%, respectively, in the primary group and 1.4% and 4.3%, respectively, in the salvage cystectomy group. Thirty-day mortality between 1970 and 2005 was not statistically significant in the primary and salvage groups (4.2% and 7.1%, respectively).
This large series from a high-volume centre demonstrates no difference in perioperative mortality in primary or postradiation salvage radical cystectomy. Similarly, there was no significant difference in the incidence of most of the surgical or medical complications in either group, although the stomal stenosis rate was higher postradiation.
Keywords: Bladder cancer, Cystectomy, Radiotherapy, Postradiotherapy salvage cystectomy, Pelvic exenteration, Urinary diversion, Postoperative complications.
a The Christie Hospital NHS Foundation Trust, Manchester, United Kingdom
b The University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
c Salford Royal NHS Foundation Trust, Salford, United Kingdom
Corresponding author. The Christie Hospital Foundation Trust, Wilmslow Road, Manchester M20 4BX, UK. Tel. +44 161 446 3363.
© 2009 European Association of Urology, Published by Elsevier B.V.