To clarify the role of radical prostatectomy (RP) in the treatment of locally advanced and high-grade prostate cancer.
Literature search of Medline publications on surgery for locally advanced and high-grade prostate cancer.
In patients with locally advanced disease, the cancer-specific survival rate after RP at 5- and 10-yr follow-up was 85–100% and 57–91.6%, respectively. The overall survival rate at 5 and 10 yr was
It is likely that surgery has a role in the treatment of locally advanced and high-grade tumours. However, it is necessary and urgent to have randomised trials assessing survival and quality of life when RP is and is not included in the multimodality treatment.
Keywords: Gleason score, High-grade, Locally advanced, Prostate cancer, Radical prostatectomy, Survival.
Department of Urology, University Hospital, K.U. Leuven, Leuven, Belgium
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© 2007 European Association of Urology, Published by Elsevier B.V.