Alfuzosin 10mg is a uroselective α1-adrenoceptor antagonist used to treat lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Recent studies have suggested the potential efficacy of alfuzosin in the treatment of distal ureteral stones and prostatitis syndrome, two conditions frequently encountered in young patients. The objective of this study was to evaluate the effect of 10mg alfuzosin on blood pressure (BP) and heart rate (HR) in young healthy volunteers.
Materials and methods
In a randomized, double-blind, placebo-controlled, crossover study, the effect of alfuzosin 10mg on BP and HR was evaluated in 14 male volunteers (mean age: 28 yr; range: 24–30). BP<135/85 obtained in two separated measurements was a main inclusion criterion. Patients were then randomized to alfuzosin (10mg once a day) or placebo for 1 wk, followed by a washout week, and then crossed over to the other treatment. Patients were instructed to self-measure systolic (SBP) and diastolic (DBP) blood pressure and HR every hour between 8am and 8pm during the first and the last day of each cycle treatment.
All 14 enrolled volunteers completed the study. No significant difference in either SBP, DBP, or HR was observed between the placebo and alfuzosin groups at baseline. Alfuzosin did not affect SBP, DBP, or HR. No hypotensive episode (SBP reduction >10%) was recorded during each treatment.
This study shows that alfuzosin 10mg is well tolerated by young healthy subjects and may therefore be safely administered to young normotensive patients affected by distal ureteral stones and prostatitis.
Take Home Message
Alfuzosin 10mg is well tolerated by young healthy subjects, because it affects neither BP nor HR, nor produces hypotensive episodes. These results support, from a pharmacodynamic point of view, use of α1-adrenoceptor antagonists in prostatitis and distal ureteral colic.
Keywords: Alfuzosin, α1-adrenoceptor antagonist, BPH, Young healthy volunteers, Prostatitis, Distal ureteral stones.
Urology Division, S. Maria Annunziata Hospital, University of Florence, Florence, Italy
Section of Urology, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
Section of Geriatrics, Department of Critical Care Medicine and Surgery, University of Florence, Florence, Italy
Department of Urology, University of Novara, Novara, Italy
Corresponding author. Tel. +39 055 2326051; Fax: +39 055 2496452.
© 2006 European Association of Urology, Published by Elsevier B.V.