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European UrologyVolume 49, issue 6, pages 939-1152, June 2006
[Editorial Comment by Sam. McClinton]
A Critical Analysis of Nonsurgical Treatment of Peyronie's Disease
Accepted 21 February 2006, Published online 20 March 2006, pages 987 - 997
Because the efficacy of nonsurgical therapy of Peyronie's disease is controversial, this review analyses the current status of conservative therapy of Peyronie's disease.
A systematic survey on results of studies published as original papers in peer-reviewed journals is provided.
Oral drug therapies include potassium para-aminobenzoate (Potaba), vitamin E, colchicine, tamoxifen, propoleum, acetyl-l-carnitine, and propionyl-l-carnitine. Verapamil, interferon-α2a and interferon-α2b, collagenase, cortisone, hyaluronidase, and superoxide dismutase are considered intralesional therapies that have had various degrees of success. Other treatments include local gels, iontophoresis, extracorporeal shock wave therapy, and radiation.
This review analyses the current status of the conservative therapy of Peyronie's disease, because the efficacy of the nonsurgical therapy is controversial.
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