To update the complications of transurethral resection of the prostate (TURP), including management and prevention based on technological evolution.
Based on a MEDLINE search from 1989 to 2005, the 2003 results of quality management of Baden-Württemberg, and long-term personal experience at three German centers, the incidence of complications after TURP was analyzed for three subsequent periods: early (1979–1994); intermediate (1994–1999); and recent (2000–2005) with recommendations for management and prevention.
Technological improvements such as microprocessor-controlled units, better armamentarium such as video TUR, and training helped to reduce perioperative complications (recent vs. early) such as transfusion rate (0.4% vs. 7.1%), TUR syndrome (0.0% vs. 1.1%), clot retention (2% vs. 5%), and urinary tract infection (1.7% vs. 8.2%). Urinary retention (3% vs. 9%) is generally attributed to primary detrusor failure rather than to incomplete resection. Early urge incontinence occurs in up to 30–40% of patients; however, late iatrogenic stress incontinence is rare (<0.5%). Despite an increasing age (55% of patients are older than 70), the associated morbidity of TURP maintained at a low level (<1%) with a mortality rate of 0–0.25%. The major late complications are urethral strictures (2.2–9.8%) and bladder neck contractures (0.3–9.2%). The retreatment rate range is 3–14.5% after five years.
TURP still represents the gold standard for managing benign prostatic hyperplasia with decreasing complication rates. Technological alternatives such as bipolar and laser treatments may further minimize the risks of this technically difficult procedure.
Keywords: Benign Prostatic Hyperplasia (BPH), Transurethral Resection of the Prostate (TURP), Complications, Morbidity.
Despite the introduction of alternative techniques, transurethral resection of the prostate (TURP) still represents the gold standard in the operative management of benign prostatic hyperplasia (BPH) , , , , , , and . TURP underwent significant technical improvements during the last decade with major impact on the incidence of intra- and postoperative complications. On behalf of the European Society of Uro-technology, we focused on actual TURP practices
MEDLINE search on indications, techniques, technology, and incidence of complications after TURP in larger studies or randomized clinical trials included more than 9000 patients , , , , , , , , , , , , , , , , , , , , and . We classified the relevant studies into three groups according to the periods of publication: early (1979–1993); intermediate (1994–1999); and recent (2000–2005). Additionally, we analyzed the 2003 results of the urological quality assessment group of Baden-Württemberg, which include our own data in Heilbronn
3.1. Indications for TURP
- - Recurrent urinary tract infection (UTI) caused by bladder outlet obstruction
- - Recurrent episodes of urinary retention
- - Bladder calculi
- - Recurrent hematuria caused by bladder outlet obstruction
- - Renal insufficiency caused by BPH
Bladder calculi may not be regarded as an absolute indication because only a small percentage of patients (8%) needed prostate surgery after ESWL in a recent study
Contraindications represent untreated UTI and coagulation disorders. High-risk patients have to be checked carefully by the cardiologist or anesthesiologist to minimize the risk of associated morbidity (
3.2. Resection techniques
Various systematic approaches to TURP have been proposed: In 1943, Nesbit described a procedure that starts with the ventral parts of the gland (between 11 and 1 o’clock), followed by both lateral lobes, the mid-lobe, and finishing with the apex
3.3. TURP technology
Electroresection is performed by monopolar, high-frequency current with a maximum cutting power of 200 watts  and . A microprocessor-controlled electrical unit with an active electrode that transduces permanent signals to the processor allows real-time power adjustment
Coagulating intermittent cutting was developed to realize blood-sparing TURP by modifying a standard high-frequency generator: phases with a predominant cutting effect alternate with coagulating phases of constant pulses under the control of pulse intervals
Other instrumental alternatives to decrease TURP morbidity include modified electrode shapes (thick loop)
Recently, manufacturers such as Gyrus, Vista-ACMI, Olympus, and Karl Storz introduced bipolar devices that differ with respect to the loop shape and technical solution of bipolar TURP (active and return electrode) , , , and . High-frequency (HF) energy up to 160 watts passes through the conductive irrigation solution of 0.9% sodium chloride. This results in a vapor layer of plasma that contains energy-charged particles that induce tissue disintegration through molecular dissociation
3.4. Laser prostatectomy
Alternative ablative technologies include Holmium-YAG laser resection , , and  or ablation  and  and KTP-laser photoselective vaporization of the prostate
3.5. Intra-operative complications
Arterial bleeding can be more pronounced in cases of preoperative infection or urinary retention because of a congested gland. Anti-androgen pretreatment with finasteride or flutamide may reduce bleeding
3.6.1. Technical aspects
According to the literature about resection techniques , , , and , vascular control of prostatic vessels differs. In the Mauermeyer approach  and  the vessels at 5 and 7 o’clock are controlled early; the Nesbit technique
The following problems with arterial bleeders may occur during resection
- - Arterial flow is directed to the optic
- - Bleeding is covered by a coagulum or behind prostatic tissue
- - Bleeding is close to the apex (12 o’clock position) or bladder neck
In larger arteries, a resectoscope might be used to compress the bleeding. After that, the optimal angle for visualizing the bleeding stump must be found to avoid any arterial flow directed to the optic (
Venous bleeders may cause an influx of irrigation fluid if they are not visible during resection. However, if the bladder is empty, the fluid is dark red. Venous sinusoids can be coagulated, but must be done very carefully if there is associated capsular perforation to avoid aggravating the perforation. Smaller veins can be occluded with a three-way-balloon catheter at the end of the TUR (
3.6.3. Balloon compression
The catheter should be blocked with 20 cc in the fossa; however, in critical cases, the balloon can be blocked in the bladder (60–80 cc) and put under traction to compress the fossa. This can be accomplished with gauze knotted around the catheter at the meatus by use of a 500
3.7. TUR syndrome
TUR syndrome is characterized by mental confusion, nausea, vomiting, hypertension, bradycardia, and visual disturbances. It is caused by dilutional hyponatremia (serum sodium <125
With any suspicion of TUR syndrome, serum sodium levels must be checked immediately. Adding ethyl alcohol to the irrigant may allow early detection of influx by permitting analysis of the alcohol content in the exsufflated air  and . However, because of the low incidence of TUR syndrome, we do not recommend this as routine treatment.
This occurs when the capsule is injured or the bladder neck is divided (
If the irrigation input does not correlate with the output and a palpable increase in abdominal pressure, an ultrasound is necessary to identify intra- or retroperitoneal fluid collection. Usually this is associated with complications such as abdominal pain and respiratory insufficiency, and requires drainage.
3.8.2. Management and prevention
In cases of extraperitoneal extravasation, forced diuresis (20–40
3.9. Injury of orifices
Such a lesion may occur when large mid-lobes are resected and the ureteral orifice is difficult to identify. As in TUR of bladder tumors, the management depends on the severity of the lesion.
3.9.1. Management and prevention
In cases of severe urethral injury a DJ-stent may be indicated; otherwise, sonographic follow-up is sufficient. The stent should be kept indwelling for two to three weeks. The orifices should be identified before TURP starts. If this is not possible because of a large mid-lobe, TURP should be performed very carefully, particularly close to the bladder neck. Suprapubic cystoscopy can be helpful in this situation
3.10. Injury of external sphincter
Most forms of postoperative incontinence are not caused by iatrogenic trauma of the external sphincter muscle. The lesion usually occurs ventrally (at 12 o’clock), where the veru montanum (ejaculatory duct) is not visible. Also, there is an increased risk of sphincteric injury if the veru has already been resected.
The exact location of the external sphincter should be checked repeatedly, particularly during apical paracollicular resection
3.12. Bladder tamponade
Recurrent or persistent bleeding sometimes results in clot formations and a bladder tamponade that require evacuation or even reintervention (1.3–5%). Arterial bleeders can usually be identified by intermittent change of colour in the irrigation outflow from clear to red (cloudy red spots), whereas venous bleeders result in a dark red continuous irrigation fluid.
Obstructing clots should generally be evacuated. The balloon catheter should then be replaced under rectal palpation. The balloon can be either blocked in the fossa or inflated in the bladder (20–40 cc more than the resection weight) and put under traction (
If the irrigation fluid does not clear in the recovery room, immediate reintervention with tamponade evacuation and bleeder coagulation is required to minimize the risk of further complications.
Occasionally, associated coagulation disorders that were undetected preoperatively may not respond to coagulation alone. In such situations, additional recto-digital palpation may stop the bleeding. Another alternative is transfemoral superselective embolization
The infection rate is usually low (e.g., in Baden-Württemberg 3.5%); however, in the French multi-centric study the incidence of post-TURP infection was 21.6%, including a 2.3% rate of septic shock
- - Preoperative bacturia
- - Longer duration of the procedure (>70min.)
- - Preoperative stay longer than two days
- - Discontinuation of catheter drainage (tamponade evacuation)
The low rate in Heilbronn (1.7%) is based on routine preoperative urinalysis to rule out any significant untreated UTI. This might be problematic in cases of indwelling catheters. We recommend antibiotic prophylaxis such as cotrimoxazole or gyrase inhibitors. We also see a low incidence of postoperative epididydimitis and do not recommend routine simultaneous vasectomy.
3.14. Urinary retention
Urinary retention (3–9%) is mainly attributed to primary detrusor failure rather than to incomplete resection
Early incontinence may occur in up to 30–40% of patients; however, late iatrogenic stress incontinence occurs in fewer than 0.5% of patients.
3.15.1. Early management
Incontinence after BPH surgery requires careful evaluation  and . Early incontinence is usually urge symptomatic, either because of irritative symptoms such as fossa healing and associated UTI or detrusor instability caused by long-lasting BPH
3.15.2. Urodynamic evaluation
Incontinence that persists longer than six months requires complete investigation, including ascending urethrogram, cystourethroscopy, and urodynamic evaluation
3.15.3. Late management
Depending on endoscopic and urodynamic findings, conservative treatment with pelvic floor exercise combined with TRUS-biofeedback and electrostimulation might be indicated. Promising experiences with Duloxetine (40
3.16. Urethral stricture
- - Meatal strictures usually occur because of an inappropriate relationship between the size of the instrument and the diameter of the urethral meatus.
- - Bulbar strictures occur because insufficient isolation by the lubricant causes the monopolar current to leak.
The gel should be applied carefully in the urethra and along the shaft of the resectoscope. The lubricant must be reapplied in cases of longer resection time. Moreover, high cutting current should be avoided. An internal urethrotomy must be performed before TURP if there are pre-existing meatal or urethral strictures , , and .
3.17. Bladder neck stenosis
The incidence varies from 0.3% to 9.2%, usually after smaller glands (<30
3.18. Retrograde ejaculation
According to the nature of the procedure, retrograde ejaculation occurs in the majority of patients (53–75%). Retrograde ejaculation might be avoided if the tissue around the veru montanum is spared during resection. More importantly for younger patients, the indication for TURP should be taken seriously versus medical treatment with alpha-blockers or 5-alpha-reductase-inhibitors, or a transurethral incision of the prostate.
3.20. Recurrent BPH
The retreatment rate of TURP is lower than the rates of other alternatives such as TUMT and TUNA (3–14.5% after five years)
3.21. Associated morbidity and mortality (
Despite the increasing mean age (55% of patients are older than 70), the associated morbidity of TURP maintained a similar low level <1% with a mortality rate of 0–0.25% in large series  and . Nevertheless, TURP still has to be taken seriously, particularly with cardiac patients. Coagulation disorders should be checked preoperatively (no aspirin, clopidogel (oumadine)).
Mortality after TURP has decreased substantially during the past few decades to <0.25% in contemporary series (
4.1. Intraoperative complications
The major intraoperative complication remains hemorrhaging that requires blood transfusions. Technical improvements of monopolar HF generators  and  and the instrumentarium , , and  resulted in a significant decrease of transfusion rates. Whereas in early series, transfusion rates of up to 22% were reported, the incidence has decreased to 0.4–7.1% (
TUR syndrome largely disappeared with the use of modern irrigation fluids, improved surgical techniques, and instrumentation (low pressure). The incidence decreased from >2% to <1% (Table 1 and Table 2). Heidler
4.2. Resection speed
Some complications are related to prolonged operating times. Despite all technical improvements, overall data reveal no decrease in resection speed of 0.5–0.9
4.3. Postoperative complications
Most frequent complications within the first four to six weeks after TURP are prolonged urinary retention, postoperative bleeding with clot retention, and UTI. The rate of clot retention with major bleeding was 2–5% in recent studies
Few data reveal the relationship of the applied electric energy and the irritative symptoms postoperatively. Nevertheless, the amount of energy should be minimized
The major two late complications are urethral strictures (2.2–9.8%) and bladder neck contractures (0.3–9.2%). Despite improvements in surgical techniques, lubricants, instruments, and electrical technology, the incidence of urethral strictures did not change significantly (
The controversy about erectile dysfunction after TURP was clarified by the Veterans Affairs cooperative study group that compared TURP with watchful waiting
The morbidity of contemporary TURP is lower than previously reported. This is based on a continuously improving armamentarium and technique, but is also related to a significant improvement in teaching modalities, including video technology such as video TUR, hands-on courses with phantoms, TURP courses with live demonstrations, and textbooks with CD-ROMs that demonstrate the steps of the technique
This is an important review paper which should be used in the future as a reference for comparison studies regarding new techniques and technologies for BPH treatment. As a matter of fact, the incidence of significant bleeding and late incontinence mainly contributed in the past to the definition of TURP as an “invasive” operation and nowadays it is greatly decreased. Blood replacement has become hepisodical and permanent incontinence is less than 0.5%. Bipolar technology might in the future even reduce the complication rate avoiding the already rare TUR syndrome. TURP is still a difficult operation with a consistent learning curve, but I presume that in the future review papers it could be rightly listed within the “non-invasive” procedure for the treatment of BPH.
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a Department of Urology, SLK Kliniken Heilbronn, University of Heidelberg, Germany
b Department of Urology, Auguste Victoria Klinikum Berlin, Germany
c Department of Urology, Phillips-University Marburg, Germany
© 2005 European Association of Urology, Published by Elsevier B.V.