The Utility of Tamsulosin in the Management of Orgasm-Associated Pain: A Pilot Analysis

By: Jennifer Barnas a , Marilyn Parker b , Patricia Guhring a and John P. Mulhall a *

European Urology, Volume 47 Issue 3, October 2015, Pages 361-365

Published online: 29 October 2015

Keywords: Orgasm, Pain, Alpha-blocker, Tamsulosin

Abstract Full Text Full Text PDF (159 KB)



Orgasmic pain is an infrequently reported but distressing problem for the patients who experience it. No consensus exists as to its etiology however bladder neck/pelvic floor spasm may play a role. This analysis was conducted to assess the effect of the alpha-blocking medication, tamsulosin on post-orgasmic pain.


In a prospective, non-placebo controlled study, patients with orgasmic pain were interviewed and administered tamsulosin 0.4 mg po qhs for at least 4 weeks. Outcome measures included libido, pain and continence and these were evaluated using the International Index of Erectile Function (IIEF), a visual analog scale (VAS) for pain and an incontinence scale respectively pre and post treatment. Patients were separated into groups based on etiology of the problem (radical prostatectomy, radiation therapy, and other) for statistical analysis.


98 patients were enrolled. Pain was located predominantly in the penis (72%), with other sites including testis, rectum and abdomen. Most patients (52%) experienced pain for less than 5 minutes post-orgasm. 76/98 (77%) patients reported significant improvement in pain (≥2 points on pain VAS) and 12/98 (12%) noted complete resolution of their pain. The VAS for pain reflected a statistically significant decrease in pain for all groups in response to tamsulosin treatment. The entire group had a decrease of 2.7 points between pre and post-treatment phases. The IIEF libido domain increased significantly (mean of 2.4 points) for all treatment groups.


Tamsulosin decreases orgasmic pain intensity in patients with orgasmic pain. These data support the hypothesis that orgasmic pain is related to bladder neck and/or pelvic floor muscle spasm.

Keywords: Orgasm, Pain, Alpha-blocker, Tamsulosin.


a Department of Urology, Weill Medical College of Cornell University, New York Presbyterian Hospital, 525 E 68th Street, Starr 900, NY 10021, USA

b Department of Urology, Loyola University Medical Center, Stritch School of Medicine, Maywood, IL, USA

* Corresponding author. Tel. +1 212 746 5653; Fax: +1 212 746 0403.

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